Identification of Somatic Mutations in Papanicolaou Smear DNA and Plasma Circulating Cell-Free DNA for Detection of Endometrial and Epithelial Ovarian Cancers: A Pilot Study

Identification of Somatic Mutations in Papanicolaou Smear DNA and Plasma Circulating Cell-Free DNA for Detection of Endometrial and Epithelial Ovarian Cancers: A Pilot Study

ObjectivesThe aim of this study was to identify tumor-derived DNA from Papanicolaou (Pap) smear and plasma specimens collected from patients with endometrial cancer or atypical hyperplasia (EC/AH) or epithelial ovarian cancer (OC).MethodsTumor tissues, peripheral blood, and Pap smear samples were co...

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Bibliographic Details
Main Authors: Xuan Jiang, Weihua Li, Jiaxin Yang, Shuzhen Wang, Dongyan Cao, Mei Yu, Keng Shen, Jian Bai, Yang Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
somatic mutation
endometrial cancer
epithelial ovarian cancer
circulating cell-free DNA
Papanicolaou smear
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.582546/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.582546/full

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