Tributyrin Mitigates Ethanol-Induced Lysine Acetylation of Histone-H3 and p65-NFκB Downregulating CCL2 Expression and Consequent Liver Inflammation and Injury

Tributyrin Mitigates Ethanol-Induced Lysine Acetylation of Histone-H3 and p65-NFκB Downregulating CCL2 Expression and Consequent Liver Inflammation and Injury

Purpose: Chemokine-driven leukocyte infiltration and sustained inflammation contribute to alcohol-associated liver disease (ALD). Elevated hepatic CCL2 expression, seen in ALD, is associated with disease severity. However, mechanisms of CCL2 regulation are not completely elucidated. Post-translation...

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Bibliographic Details
Main Authors: Smita S. Ghare, Benjamin T. Charpentier, Dushan T. Ghooray, Jingwen Zhang, Manicka V. Vadhanam, Sreelatha Reddy, Swati Joshi-Barve, Craig J. McClain, Shirish S. Barve
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Nutrients
Subjects:
alcohol
histone H3 acetylation
p300
SIRT1
CCL2 promoter
tributyrin
Online Access:https://www.mdpi.com/2072-6643/15/20/4397

Internet

https://www.mdpi.com/2072-6643/15/20/4397

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