Methamphetamine induces transcriptional changes in cultured HIV-infected mature monocytes that may contribute to HIV neuropathogenesis

Methamphetamine induces transcriptional changes in cultured HIV-infected mature monocytes that may contribute to HIV neuropathogenesis

HIV-associated neurocognitive impairment (HIV-NCI) persists in 15-40% of people with HIV (PWH) despite effective antiretroviral therapy. HIV-NCI significantly impacts quality of life, and there is currently no effective treatment for it. The development of HIV-NCI is complex and is mediated, in part...

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Bibliographic Details
Main Authors: Vanessa Chilunda, Jessica Weiselberg, Samuel Martinez-Meza, Lwidiko E. Mhamilawa, Laura Cheney, Joan W. Berman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
methamphetamine
monocytes
HIV
neuroinflammation
migration
viral reservoirs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.952183/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.952183/full

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