The Inherent Coupling of Intrinsically Disordered Regions in the Multidomain Receptor Tyrosine Kinase KIT

The Inherent Coupling of Intrinsically Disordered Regions in the Multidomain Receptor Tyrosine Kinase KIT

RTK KIT regulates a variety of crucial cellular processes via its cytoplasmic domain (CD), which is composed of the tyrosine kinase domain, crowned by the highly flexible domains—the juxtamembrane region, kinase insertion domain, and C-tail, which are key recruitment regions for downstream signallin...

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Bibliographic Details
Main Authors: Julie Ledoux, Alain Trouvé, Luba Tchertanov
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
receptor tyrosine kinase (RTK)
full-length KIT cytoplasmic region
intrinsically disordered regions
phosphotyrosine
modelling
molecular dynamics
Online Access:https://www.mdpi.com/1422-0067/23/3/1589

Internet

https://www.mdpi.com/1422-0067/23/3/1589

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