Characterizing metabolic drivers of Clostridioides difficile infection with activity-based hydrazine probes

Characterizing metabolic drivers of Clostridioides difficile infection with activity-based hydrazine probes

Many enzymes require post-translational modifications or cofactor machinery for primary function. As these catalytically essential moieties are highly regulated, they act as dual sensors and chemical handles for context-dependent metabolic activity. Clostridioides difficile is a major nosocomial pat...

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Bibliographic Details
Main Authors: Katelyn A. Bustin, Arwa Abbas, Xie Wang, Michael C. Abt, Joseph P. Zackular, Megan L. Matthews
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
cofactor
ABPP
Clostridioides difficile infection
druggable modality
Stickland fermentation
hydrazine pharmacophore
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1074619/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1074619/full

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