Cistrome and transcriptome analysis identifies unique androgen receptor (AR) and AR-V7 splice variant chromatin binding and transcriptional activities

Cistrome and transcriptome analysis identifies unique androgen receptor (AR) and AR-V7 splice variant chromatin binding and transcriptional activities

Abstract The constitutively active androgen receptor (AR) splice variant, AR-V7, plays an important role in resistance to androgen deprivation therapy in castration resistant prostate cancer (CRPC). Studies seeking to determine whether AR-V7 is a partial mimic of the AR, or also has unique activitie...

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Bibliographic Details
Main Authors: Paul Basil, Matthew J. Robertson, William E. Bingman, Amit K. Dash, William C. Krause, Ayesha A. Shafi, Badrajee Piyarathna, Cristian Coarfa, Nancy L. Weigel
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-09371-x

Internet

https://doi.org/10.1038/s41598-022-09371-x

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