Increased Tc22 and Treg/CD8 ratio contribute to aggressive growth of transplant associated squamous cell carcinoma.

Increased Tc22 and Treg/CD8 ratio contribute to aggressive growth of transplant associated squamous cell carcinoma.

Immune suppressed organ transplant recipients suffer increased morbidity and mortality from primary cutaneous SCC. We studied tumor microenvironment in transplant-associated SCC (TSCC), immune-competent SCC and normal skin by IHC, IF and RT-PCR on surgical discard. We determined T cell polarization...

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Bibliographic Details
Main Authors: Shali Zhang, Hideki Fujita, Hiroshi Mitsui, Valerie R Yanofsky, Judilyn Fuentes-Duculan, Julia S Pettersen, Mayte Suárez-Fariñas, Juana Gonzalez, Claire Q F Wang, James G Krueger, Diane Felsen, John A Carucci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3646982?pdf=render

Internet

http://europepmc.org/articles/PMC3646982?pdf=render

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