Targeted Synthesis and Antitumor Activity In Vitro Macrodiolides Containing 1<i>Z</i>,5<i>Z</i>-Diene and 1,3-Diyne Moieties

Targeted Synthesis and Antitumor Activity In Vitro Macrodiolides Containing 1<i>Z</i>,5<i>Z</i>-Diene and 1,3-Diyne Moieties

Efficient methods have been developed for synthesizing previously unknown macrodiolides incorporating 1<i>Z</i>,5<i>Z</i>-diene and 1,3-diyne moieties in 54–84% yields and with >98% stereoselectivity by means of the intermolecular cyclocondesation of (7<i>Z</i>...

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Bibliographic Details
Main Authors: Ilgiz Islamov, Adelya Yusupova, Lilya U. Dzhemileva, Usein Dzhemilev
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Chemistry Proceedings
Subjects:
macrodiolides
1,5-dienoic compounds
1,3-diynes
1,2-dienes
cyclomagnesiation
homogeneous catalysis
Online Access:https://www.mdpi.com/2673-4583/8/1/6

Internet

https://www.mdpi.com/2673-4583/8/1/6

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