Monoclonal Antibody Functionalized, and L-lysine α-Oxidase Loaded PEGylated-Chitosan Nanoparticle for HER2/Neu Targeted Breast Cancer Therapy

Monoclonal Antibody Functionalized, and L-lysine α-Oxidase Loaded PEGylated-Chitosan Nanoparticle for HER2/Neu Targeted Breast Cancer Therapy

Herein, we designed a nanocarrier to deliver the LO specifically to HER2+ breast cancer (BC) cells, where functionalization of mAb (anti-HER2+) with PEGylated chitosan enabled it to target the HER2+ BC cells. Taking advantage of overexpression of HER2+ in cancer cells, our nanocarrier (CS-LO-PEG-HER...

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Bibliographic Details
Main Authors: Kandasamy Saravanakumar, Anbazhagan Sathiyaseelan, Soyoung Park, Song-Rae Kim, Veeraraghavan Vishnu Priya, Myeong-Hyeon Wang
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceutics
Subjects:
L-lysine α-oxidase
HER2+
trastuzumab
breast cancer
PEGylated chitosan
Online Access:https://www.mdpi.com/1999-4923/14/5/927

Internet

https://www.mdpi.com/1999-4923/14/5/927

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