Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

Several lines of evidence suggest that accumulation of aggregated alpha-synuclein (α-synuclein) in the central nervous system (CNS) is an early pathogenic event in Parkinson's disease and other Lewy body disorders. In recent years, animal studies have indicated immunotherapy with antibodies dir...

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Bibliographic Details
Main Authors: Veronica Lindström, Therese Fagerqvist, Eva Nordström, Fredrik Eriksson, Anna Lord, Stina Tucker, Jessica Andersson, Malin Johannesson, Heinrich Schell, Philipp J. Kahle, Christer Möller, Pär Gellerfors, Joakim Bergström, Lars Lannfelt, Martin Ingelsson
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Neurobiology of Disease
Subjects:
Protofibril-selective antibody
Immunization
α-Synuclein transgenic mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001272

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http://www.sciencedirect.com/science/article/pii/S0969996114001272

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