Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported <i>Alox5<sup>−/−</sup></i> Mice

Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported <i>Alox5<sup>−/−</sup></i> Mice

Arachidonic acid 5-lipoxygenase (ALOX5) is the key enzyme in the biosynthesis of pro-inflammatory leukotrienes. We recently created knock-in mice (<i>Alox5</i>-KI) which express an arachidonic acid 15-lipoxygenating Alox5 mutant instead of the 5-lipoxygenating wildtype enzyme. These mice...

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Bibliographic Details
Main Authors: Eugenia Marbach-Breitrück, Nadine Rohwer, Carmen Infante-Duarte, Silvina Romero-Suarez, Dominika Labuz, Halina Machelska, Laura Kutzner, Nils Helge Schebb, Michael Rothe, Pallu Reddanna, Karsten H. Weylandt, Lothar H. Wieler, Dagmar Heydeck, Hartmut Kuhn
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Metabolites
Subjects:
eicosanoids
lipoxygenase
inflammation
pain
leukotrienes
resolvins
Online Access:https://www.mdpi.com/2218-1989/11/10/698

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https://www.mdpi.com/2218-1989/11/10/698

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