The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity
The transcription of HIV-1 (HIV) is regulated by complex mechanisms involving various cellular factors and virus-encoded transactivators. Poly(ADP-ribose) polymerase 1 (PARP-1) inhibition has emerged recently as a potent anti-inflammatory tool, since PARP-1 is involved in the regulation of some gene...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-08-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00878/full |