Copper-catalysed asymmetric allylic alkylation of alkylzirconocenes to racemic 3,6-dihydro-2H-pyrans

Copper-catalysed asymmetric allylic alkylation of alkylzirconocenes to racemic 3,6-dihydro-2H-pyrans

Asymmetric allylic alkylation is a powerful reaction that allows the enantioselective formation of C–C bonds. Here we describe the asymmetric alkylation of alkylzirconium species to racemic 3,6-dihydro-2H-pyrans. Two systems were examined: 3-chloro-3,6-dihydro-2H-pyran using linear optimization (45–...

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Bibliographic Details
Main Authors: Emeline Rideau, Stephen P. Fletcher
Format: Article
Language:English
Published: Beilstein-Institut 2015-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
allylic alkylation
asymmetric catalysis
copper
design of experiments
dynamic kinetic asymmetric transformation
heterocycles
Schwartz reagent
Online Access:https://doi.org/10.3762/bjoc.11.264

Internet

https://doi.org/10.3762/bjoc.11.264

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