Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

Abstract Interleukin-37b (hereafter called IL-37) was identified as fundamental inhibitor of natural and acquired immunity. The molecular mechanism and function of IL-37 in colorectal cancer (CRC) has been elusive. Here, we found that IL-37 transgenic (IL-37tg) mice were highly susceptible to coliti...

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Main Authors: Zhen Wang, Fan-lian Zeng, Ya-wen Hu, Xiao-yan Wang, Fu-lei Zhao, Pei Zhou, Jing Hu, Yuan-yuan Xiao, Zhong-lan Hu, Ming-feng Guo, Xiao-qiong Wei, Xiao Liu, Nong-yu Huang, Jun Zhang, Shu-wen Chen, Juan Cheng, Hua-ping Zheng, Hong Zhou, Qi-xiang Zhao, Chen Zhang, Yan Hao, Song Zou, Yi-yue Gui, Jia-dong Yu, Lin-na Gu, Cheng-cheng Yue, Hao-zhou Zhang, Wen-ling Wu, Yi-fan Zhou, Xi-kun Zhou, Guo-bo Shen, Xiu Teng, Jiong Li
Format: Article
Language:English
Published: Nature Publishing Group 2022-01-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00820-z

Internet

https://doi.org/10.1038/s41392-021-00820-z

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