Cortical Tonic Inhibition Gates the Expression of Spike-and-Wave Discharges Associated with Absence Epilepsy

Cortical Tonic Inhibition Gates the Expression of Spike-and-Wave Discharges Associated with Absence Epilepsy

Objective: Absence seizures result from aberrant thalamocortical processing that confers synchronous, bilateral spike-and-wave discharges (SWDs) and behavioral arrest. Previous work has demonstrated that SWDs can result from enhanced thalamic tonic inhibition, consistent with the mechanism of first-...

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Bibliographic Details
Main Authors: Kile P. Mangan, Aaron B. Nelson, Steven Petrou, Chiara Cirelli, Mathew V. Jones
Format: Article
Language:English
Published: IMR Press 2024-01-01
Series:Journal of Integrative Neuroscience
Subjects:
epilepsy
absence epilepsy
tonic inhibition
neurosteroids
ganaxolone
Online Access:https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301024

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https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301024

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