The Effects of Intramuscular Naloxone Dose on Mu Receptor Displacement of Carfentanil in Rhesus Monkeys

The Effects of Intramuscular Naloxone Dose on Mu Receptor Displacement of Carfentanil in Rhesus Monkeys

Naloxone (NLX) is a mu receptor antagonist used to treat acute opioid overdoses. Currently approved doses of naloxone to treat opioid overdoses are 4 mg intranasal (IN) and 2 mg intramuscular (IM). However, higher mu receptor occupancy (RO) may be required to treat overdoses due to more potent synth...

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Bibliographic Details
Main Authors: Peter J. H. Scott, Robert A. Koeppe, Xia Shao, Melissa E. Rodnick, Alexandra R. Sowa, Bradford D. Henderson, Jenelle Stauff, Phillip S. Sherman, Janna Arteaga, Dennis J. Carlo, Ronald B. Moss
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
opioid
naloxone
overdose
fentanyl
carfentanil
[<sup>11</sup>c]carfentanil
positron emission tomography
receptor occupancy
pharmacokinetics
Online Access:https://www.mdpi.com/1420-3049/25/6/1360

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https://www.mdpi.com/1420-3049/25/6/1360

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