Chronic Ethanol Consumption Impairs the Tactile-Evoked Long-Term Depression at Cerebellar Molecular Layer Interneuron-Purkinje Cell Synapses in vivo in Mice

Chronic Ethanol Consumption Impairs the Tactile-Evoked Long-Term Depression at Cerebellar Molecular Layer Interneuron-Purkinje Cell Synapses in vivo in Mice

The cerebellum is sensitive to ethanol (EtOH) consumption. Chronic EtOH consumption impairs motor learning by modulating the cerebellar circuitry synaptic transmission and long-term plasticity. Under in vitro conditions, acute EtOH inhibits both parallel fiber (PF) and climbing fiber (CF) long-term...

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Bibliographic Details
Main Authors: Da-Yong Li, Yan-Hua Bing, Chun-Ping Chu, Xun Cui, Song-Biao Cui, De-Lai Qiu, Li-Da Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ethanol
cerebellar purkinje cell
molecular layer interneuron
sensory stimulation
plasticity
nitric oxide
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00521/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00521/full

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