Toll-Like Receptor- and Protein Kinase R-Induced Type I Interferon Sustains Infection of Leishmania donovani in Macrophages

Toll-Like Receptor- and Protein Kinase R-Induced Type I Interferon Sustains Infection of Leishmania donovani in Macrophages

Leishmania donovani is a protozoan parasite that causes visceral leishmaniasis, provoking liver and spleen tissue destruction that is lethal unless treated. The parasite replicates in macrophages and modulates host microbicidal responses. We have previously reported that neutrophil elastase (NE) is...

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Bibliographic Details
Main Authors: Bruna T. Dias, Amy Goundry, Aislan C. Vivarini, Tatiana F. R. Costa, Jeremy C. Mottram, Ulisses G. Lopes, Ana Paula C. A. Lima
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
Leishmania
interferon
PKR
TLR
neutrophil elastase (NE)
ecotin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.801182/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.801182/full

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