Protonation State of an Important Histidine from High Resolution Structures of Lytic Polysaccharide Monooxygenases

Protonation State of an Important Histidine from High Resolution Structures of Lytic Polysaccharide Monooxygenases

Lytic Polysaccharide Monooxygenases (LPMOs) oxidatively cleave recalcitrant polysaccharides. The mechanism involves (i) reduction of the Cu, (ii) polysaccharide binding, (iii) binding of different oxygen species, and (iv) glycosidic bond cleavage. However, the complete mechanism is poorly understood...

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Bibliographic Details
Main Authors: Sanchari Banerjee, Sebastian J. Muderspach, Tobias Tandrup, Kristian Erik Høpfner Frandsen, Raushan K. Singh, Johan Ørskov Ipsen, Cristina Hernández-Rollán, Morten H. H. Nørholm, Morten J. Bjerrum, Katja Salomon Johansen, Leila Lo Leggio
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biomolecules
Subjects:
polysaccharide monooxygenase
protonation
stereochemical properties
partial unrestrained refinement
auxiliary activities
Online Access:https://www.mdpi.com/2218-273X/12/2/194

Internet

https://www.mdpi.com/2218-273X/12/2/194

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