Maternal periconceptional environmental exposure and offspring with congenital heart disease: a case–control study in Guangzhou, China
Abstract Background Congenital heart defects (CHDs) are a major global health problem, yet their crucial environmental risk factors are still unclear. We aimed to explore the associations between maternal periconceptional environmental exposures and all CHDs, isolated and multiple CHDs and CHDs subt...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-023-05355-5 |
| _version_ | 1811175709121445888 |
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| author | Di Xiao Weidong Li Wei-Hong Zhang Zihao Wen Weijian Mo Ciyong Lu Lan Guo Li Yang |
| author_facet | Di Xiao Weidong Li Wei-Hong Zhang Zihao Wen Weijian Mo Ciyong Lu Lan Guo Li Yang |
| author_sort | Di Xiao |
| collection | DOAJ |
| description | Abstract Background Congenital heart defects (CHDs) are a major global health problem, yet their crucial environmental risk factors are still unclear. We aimed to explore the associations between maternal periconceptional environmental exposures and all CHDs, isolated and multiple CHDs and CHDs subtypes. Method A case–control study including 675 infants with CHDs and 1545 healthy controls was conducted. Participating mothers who delivered in Guangzhou from October 2019 to November 2021 were recruited. To examine the independent associations between maternal periconceptional environmental exposure and offspring with CHDs, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression model. Results Maternal exposure to living near main roads [adjusted OR (aOR) = 1.94, 95% CI = 1.06–3.56] and housing renovation (aOR = 1.94, 95% CI = 1.03–3.67) during the periconceptional period were positively related to a greater risk of all CHDs, similar results were also found in isolated CHDs rather than multiple CHDs. Additionally, living near main roads was positively associated with secundum atrial septal defect/patent foramen ovale (aOR = 2.65, 95% CI = 1.03–6.81) and housing renovation was strongly positively associated with ventricular septal defect (aOR = 5.08, 95% CI = 2.05–12.60). However, no association was observed between incense burning and family relationships and all CHDs, isolated and multiple CHDs and CHDs subtypes. Conclusion Living near main roads and housing renovation during the periconceptional period are significantly associated with the increased risks for all CHDs and isolated CHDs. Further study is needed to extend sample size to explore the effects of time and frequency of burning incense and family relationships on CHDs in offspring. |
| first_indexed | 2024-04-10T19:40:09Z |
| format | Article |
| id | doaj.art-b3ad3fa69d9e42df8ff7a0657ca90b57 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-04-10T19:40:09Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-b3ad3fa69d9e42df8ff7a0657ca90b572023-01-29T12:24:15ZengBMCBMC Pregnancy and Childbirth1471-23932023-01-0123111010.1186/s12884-023-05355-5Maternal periconceptional environmental exposure and offspring with congenital heart disease: a case–control study in Guangzhou, ChinaDi Xiao0Weidong Li1Wei-Hong Zhang2Zihao Wen3Weijian Mo4Ciyong Lu5Lan Guo6Li Yang7Department of Comprehensive Maternal and Child Health, Guangzhou Women and Children’s Medical Center, Guangdong Provincial Clinical Research Center for Child HealthDepartment of Comprehensive Maternal and Child Health, Guangzhou Women and Children’s Medical Center, Guangdong Provincial Clinical Research Center for Child HealthInternational Centre for Reproductive Health (ICRH), Department of Public Health and Primary Care, Ghent UniversityDepartment of Comprehensive Maternal and Child Health, Guangzhou Women and Children’s Medical Center, Guangdong Provincial Clinical Research Center for Child HealthDepartment of Comprehensive Maternal and Child Health, Guangzhou Women and Children’s Medical Center, Guangdong Provincial Clinical Research Center for Child HealthDepartment of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen UniversityDepartment of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen UniversityDepartment of Comprehensive Maternal and Child Health, Guangzhou Women and Children’s Medical Center, Guangdong Provincial Clinical Research Center for Child HealthAbstract Background Congenital heart defects (CHDs) are a major global health problem, yet their crucial environmental risk factors are still unclear. We aimed to explore the associations between maternal periconceptional environmental exposures and all CHDs, isolated and multiple CHDs and CHDs subtypes. Method A case–control study including 675 infants with CHDs and 1545 healthy controls was conducted. Participating mothers who delivered in Guangzhou from October 2019 to November 2021 were recruited. To examine the independent associations between maternal periconceptional environmental exposure and offspring with CHDs, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression model. Results Maternal exposure to living near main roads [adjusted OR (aOR) = 1.94, 95% CI = 1.06–3.56] and housing renovation (aOR = 1.94, 95% CI = 1.03–3.67) during the periconceptional period were positively related to a greater risk of all CHDs, similar results were also found in isolated CHDs rather than multiple CHDs. Additionally, living near main roads was positively associated with secundum atrial septal defect/patent foramen ovale (aOR = 2.65, 95% CI = 1.03–6.81) and housing renovation was strongly positively associated with ventricular septal defect (aOR = 5.08, 95% CI = 2.05–12.60). However, no association was observed between incense burning and family relationships and all CHDs, isolated and multiple CHDs and CHDs subtypes. Conclusion Living near main roads and housing renovation during the periconceptional period are significantly associated with the increased risks for all CHDs and isolated CHDs. Further study is needed to extend sample size to explore the effects of time and frequency of burning incense and family relationships on CHDs in offspring.https://doi.org/10.1186/s12884-023-05355-5Congenital heart defectsLiving near main roadsFamily relationshipsIncense burningHousing renovation |
| spellingShingle | Di Xiao Weidong Li Wei-Hong Zhang Zihao Wen Weijian Mo Ciyong Lu Lan Guo Li Yang Maternal periconceptional environmental exposure and offspring with congenital heart disease: a case–control study in Guangzhou, China BMC Pregnancy and Childbirth Congenital heart defects Living near main roads Family relationships Incense burning Housing renovation |
| title | Maternal periconceptional environmental exposure and offspring with congenital heart disease: a case–control study in Guangzhou, China |
| title_full | Maternal periconceptional environmental exposure and offspring with congenital heart disease: a case–control study in Guangzhou, China |
| title_fullStr | Maternal periconceptional environmental exposure and offspring with congenital heart disease: a case–control study in Guangzhou, China |
| title_full_unstemmed | Maternal periconceptional environmental exposure and offspring with congenital heart disease: a case–control study in Guangzhou, China |
| title_short | Maternal periconceptional environmental exposure and offspring with congenital heart disease: a case–control study in Guangzhou, China |
| title_sort | maternal periconceptional environmental exposure and offspring with congenital heart disease a case control study in guangzhou china |
| topic | Congenital heart defects Living near main roads Family relationships Incense burning Housing renovation |
| url | https://doi.org/10.1186/s12884-023-05355-5 |
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