Heme oxygenase-1 prevents cardiac dysfunction in streptozotocin-diabetic mice by reducing inflammation, oxidative stress, apoptosis and enhancing autophagy.

Heme oxygenase-1 prevents cardiac dysfunction in streptozotocin-diabetic mice by reducing inflammation, oxidative stress, apoptosis and enhancing autophagy.

Heme oxygenase-1 (HO-1) has been implicated in cardiac dysfunction, oxidative stress, inflammation, apoptosis and autophagy associated with heart failure, and atherosclerosis, in addition to its recognized role in metabolic syndrome and diabetes. Numerous studies have presented contradictory finding...

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Bibliographic Details
Main Authors: Yanli Zhao, Lina Zhang, Yu Qiao, Xiaoling Zhou, Guodong Wu, Lujing Wang, Yahui Peng, Xingli Dong, Hui Huang, Lining Si, Xueying Zhang, Lei Zhang, Jihong Li, Wei Wang, Lingyun Zhou, Xu Gao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3782439?pdf=render

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http://europepmc.org/articles/PMC3782439?pdf=render

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