B-Cell Depletion Improves Islet Allograft Survival with Anti-CD45RB

B-Cell Depletion Improves Islet Allograft Survival with Anti-CD45RB

A short course of anti-CD45RB leads to long-term islet allograft survival and donor-specific tolerance in approximately half of immunocompetent mice. We have previously demonstrated that anti-CD45RB antibody-mediated tolerance requires B-cells for cardiac allograft survival. We therefore asked wheth...

Full description

Bibliographic Details
Main Authors:	Kang Mi Lee, Heidi Yeh, Gaoping Zhao, Lingling Wei, Matthew O'connor, Ryan T. Stott, Julie Soohoo, Kyri Dunussi, Paolo Fiorina, Shaoping Deng, James F. Markmann M.D., Ph.D., James I. Kim
Format:	Article
Language:	English
Published:	SAGE Publishing 2014-02-01
Series:	Cell Transplantation
Online Access:	https://doi.org/10.3727/096368912X658962

Similar Items

Elevated levels of interferon-γ production by memory T cells do not promote transplant tolerance resistance in aged recipients.
by: James I Kim, et al.
Published: (2013-01-01)

B cell depletion reduces the number of autoreactive T helper cells and prevents glucose-6-phosphate isomerase-induced arthritis.
by: Oliver Frey, et al.
Published: (2011-01-01)

Selective Depletion of Cross-Presenting Dendritic Cells Enhances Islet Allograft Survival
by: Robyn M. Sutherland, et al.
Published: (2011-04-01)

Innate immune signals required for islet and cardiac allograft rejection are regulated by CD45.
by: Camirand, G, et al.
Published: (2007)

Coinhibitory T-Cell Signaling in Islet Allograft Rejection and Tolerance
by: Wayne Truong, et al.
Published: (2006-02-01)

Induction of Immunological Tolerance to Islet Allografts
by: Aldo A. Rossini M.D., et al.
Published: (1996-01-01)

ICAM-1 Antisense Oligodeoxynucleotide Improves Islet Allograft Survival and Function
by: Stephen M. Katz M.D., et al.
Published: (2000-11-01)

RB depletion is required for the continuous growth of tumors initiated by loss of RB.
by: Alex Doan, et al.
Published: (2021-12-01)

RB depletion is required for the continuous growth of tumors initiated by loss of RB
by: Alex Doan, et al.
Published: (2021-12-01)

Selective Depletion of Alloreactive T Cells Leads to Long-Term Islet Allograft Survival across a Major Histocompatibility Complex Mismatch in Diabetic Mice
by: M. Hu, et al.
Published: (2013-10-01)

Effects of Acute Cytomegalovirus Infection on Rat Islet Allograft Survival
by: M. J. Smelt Ph.D., et al.
Published: (2011-09-01)

Development of an Immunoprivileged Site to Prolong Islet Allograft Survival
by: Tatsuya Kin, et al.
Published: (2002-09-01)

Decreased Survival of Islet Allografts in Rats with Advanced Chronic Complications of Diabetes
by: Wayne V. Moore M.D., Ph.D., et al.
Published: (2002-10-01)

Islet allografting in the dog model: potential therapies for tolerance induction.
by: Brons, I, et al.
Published: (1995)

Effect of Cryopreservation on the Survival and Function of Murine Islet Isografts and Allografts
by: Mark S. Cattral, et al.
Published: (1998-07-01)

Single-Cell Landscape of Mouse Islet Allograft and Syngeneic Graft
by: Pengfei Chen, et al.
Published: (2022-06-01)

IL-10 and IL-4 in Skin Allograft Survival Induced by T-Cell Depletion plus Deoxyspergualin
by: Clement Asiedu, et al.
Published: (2008-06-01)

Technique of Endoscopic Biopsy of Islet Allografts Transplanted into the Gastric Submucosal Space in Pigs
by: Minoru Fujita, et al.
Published: (2013-12-01)

Activation of Peroxisome Proliferator-Activated Receptor γ Prolongs Islet Allograft Survival
by: Hongjun Wang Ph.D., et al.
Published: (2012-10-01)

Choice of Immunosuppression Influences Cytomegalovirus DNAemia in Cynomolgus Monkey () Islet Allograft Recipients
by: Dongmei Han Ph.D., et al.
Published: (2010-12-01)

Pancreatic Islet Basement Membrane Loss and Remodeling after Mouse Islet Isolation and Transplantation: Impact for Allograft Rejection
by: H. F. Irving-Rodgers, et al.
Published: (2014-02-01)

Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection.
by: Jones, N, et al.
Published: (2001)

Pretransplant blood transfusion with additional immunotherapy tolerizes recipients to islet allografts
by: Bortecen, K, et al.
Published: (2005)

Impact of GAD65 and IA2 autoantibodies on islet allograft survival
by: Joana R. N. Lemos, et al.
Published: (2023-11-01)

HLA-B Matching Prolongs Allograft Survival in Islet Cell Transplantation
by: Joana R. N. Lemos, et al.
Published: (2023-08-01)

Failure of Nonimmunogenic Islet Allografts to Induce Donor-Specific Immunological Unresponsiveness
by: Robert J. Ketchum, et al.
Published: (1994-03-01)

Viral IL-10 Gene Transfer Prolongs Rat Islet Allograft Survival
by: Yang-Hee Kim, et al.
Published: (2008-06-01)

An Unbiased Machine Learning Exploration Reveals Gene Sets Predictive of Allograft Tolerance After Kidney Transplantation
by: Qiang Fu, et al.
Published: (2021-07-01)

Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation.
by: Nicola Gagliani, et al.
Published: (2011-01-01)

Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes
by: Amar Singh, et al.
Published: (2019-08-01)

B7-H4 Induces Donor-Specific Tolerance in Mouse Islet Allografts
by: Xiaojie Wang, et al.
Published: (2012-02-01)

Long-Term Metabolic and Hormonal Effects of Exenatide on Islet Transplant Recipients with Allograft Dysfunction
by: Raquel N. Faradji, et al.
Published: (2009-11-01)

Cell-Permeable Peptide Blocks TLR4 Signaling and Improves Islet Allograft Survival
by: Huansheng Dong, et al.
Published: (2016-07-01)

Islet Allograft Rejection in Rats: a Time Course Study Characterizing Adhesion Molecule Expression, Mhc Expression, and Infiltrate Immunophenotypes
by: Douglas A. Coddington, et al.
Published: (1998-05-01)

Development of a rat forelimb vascularized composite allograft (VCA) perfusion protocol.
by: Casie A Pendexter, et al.
Published: (2023-01-01)

Development of a rat forelimb vascularized composite allograft (VCA) perfusion protocol
by: Casie A. Pendexter, et al.
Published: (2023-01-01)

The TheraCyte™ Device Protects against Islet Allograft Rejection in Immunized Hosts
by: Makiko Kumagai-Braesch, et al.
Published: (2013-07-01)

PD-L1 Deficiency within Islets Reduces Allograft Survival in Mice.
by: Dongxia Ma, et al.
Published: (2016-01-01)

Substantial peripheral T-cell depletion before grafting is beneficial in islet transplantation.
by: Brons, I, et al.
Published: (1995)

Indefinite Survival of Rat Islet Allografts following Infusion of Donor Bone Marrow without Cytoablation
by: Camillo Ricordi M.D., et al.
Published: (1996-01-01)