Physapruin A Exerts Endoplasmic Reticulum Stress to Trigger Breast Cancer Cell Apoptosis via Oxidative Stress

Physapruin A Exerts Endoplasmic Reticulum Stress to Trigger Breast Cancer Cell Apoptosis via Oxidative Stress

<i>Physalis</i> plants are commonly used traditional medicinal herbs, and most of their extracts containing withanolides show anticancer effects. Physapruin A (PHA), a withanolide isolated from <i>P. peruviana</i>, shows antiproliferative effects on breast cancer cells involv...

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Bibliographic Details
Main Authors: Tzu-Jung Yu, Jun-Ping Shiau, Jen-Yang Tang, Ammad Ahmad Farooqi, Yuan-Bin Cheng, Ming-Feng Hou, Chia-Hung Yen, Hsueh-Wei Chang
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
withanolide
ER expansion
aggresome
caspase activation
<i>N</i>-acetylcysteine
ROS
Online Access:https://www.mdpi.com/1422-0067/24/10/8853

Internet

https://www.mdpi.com/1422-0067/24/10/8853

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