Edaravone and benidipine protect myocardial damage by regulating mitochondrial stress, apoptosis signalling and cardiac biomarkers against doxorubicin-induced cardiotoxicity

Edaravone and benidipine protect myocardial damage by regulating mitochondrial stress, apoptosis signalling and cardiac biomarkers against doxorubicin-induced cardiotoxicity

Background: Doxorubicin (DOX) is a potential chemotherapeutic agent but its use is restricted due to cardiotoxicity. Edaravone is a potent-free radical scavenging agent used in cerebral ischaemia. Benidipine is a triple calcium channel blocker. Objective: We investigated the potential cardioprotecti...

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Bibliographic Details
Main Authors: Md Quamrul Hassan, Md Sayeed Akhtar, Obaid Afzal, Ibraheem Hussain, Mohd Akhtar, Syed Ehtaishamul Haque, Abul Kalam Najmi
Format: Article
Language:English
Published: Taylor & Francis Group 2020-07-01
Series:Clinical and Experimental Hypertension
Subjects:
edaravone
benidipine
doxorubicin
mitochondrial stress
apoptosis
cardiac biomarker
Online Access:http://dx.doi.org/10.1080/10641963.2019.1676770

Internet

http://dx.doi.org/10.1080/10641963.2019.1676770

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