Extracellular vesicle mitochondrial DNA levels are associated with race and mitochondrial DNA haplogroup
Summary: Circulating cell-free mitochondrial DNA (ccf-mtDNA) acts as a damage-associated molecular pattern molecule and may be cargo within extracellular vesicles (EVs). ccf-mtDNA and select mitochondrial DNA (mtDNA) haplogroups are associated with cardiovascular disease. We hypothesized that ccf-mt...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223028018 |
| _version_ | 1797377860143415296 |
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| author | Anjali M. Byappanahalli Victor Omoniyi Nicole Noren Hooten Jessica T. Smith Nicolle A. Mode Ngozi Ezike Alan B. Zonderman Michele K. Evans |
| author_facet | Anjali M. Byappanahalli Victor Omoniyi Nicole Noren Hooten Jessica T. Smith Nicolle A. Mode Ngozi Ezike Alan B. Zonderman Michele K. Evans |
| author_sort | Anjali M. Byappanahalli |
| collection | DOAJ |
| description | Summary: Circulating cell-free mitochondrial DNA (ccf-mtDNA) acts as a damage-associated molecular pattern molecule and may be cargo within extracellular vesicles (EVs). ccf-mtDNA and select mitochondrial DNA (mtDNA) haplogroups are associated with cardiovascular disease. We hypothesized that ccf-mtDNA and plasma EV mtDNA would be associated with hypertension, sex, self-identified race, and mtDNA haplogroup ancestry. Participants were normotensive (n = 107) and hypertensive (n = 108) African American and White adults from the Healthy Aging in Neighborhoods of Diversity across the Life Span study. ccf-mtDNA levels were higher in African American participants compared with White participants in both plasma and EVs, but ccf-mtDNA levels were not related to hypertension. EV mtDNA levels were highest in African American participants with African mtDNA haplogroup. Circulating inflammatory protein levels were altered with mtDNA haplogroup, race, and EV mtDNA. Our findings highlight that race is a social construct and that ancestry is crucial when examining health and biomarker differences between groups. |
| first_indexed | 2024-03-08T19:58:29Z |
| format | Article |
| id | doaj.art-b3b7a28e2b7b4ea7b7bcbf0ce95425bb |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T19:58:29Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-b3b7a28e2b7b4ea7b7bcbf0ce95425bb2023-12-24T04:46:19ZengElsevieriScience2589-00422024-01-01271108724Extracellular vesicle mitochondrial DNA levels are associated with race and mitochondrial DNA haplogroupAnjali M. Byappanahalli0Victor Omoniyi1Nicole Noren Hooten2Jessica T. Smith3Nicolle A. Mode4Ngozi Ezike5Alan B. Zonderman6Michele K. Evans7Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USALaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USALaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USALaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USALaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USALaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USALaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USALaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA; Corresponding authorSummary: Circulating cell-free mitochondrial DNA (ccf-mtDNA) acts as a damage-associated molecular pattern molecule and may be cargo within extracellular vesicles (EVs). ccf-mtDNA and select mitochondrial DNA (mtDNA) haplogroups are associated with cardiovascular disease. We hypothesized that ccf-mtDNA and plasma EV mtDNA would be associated with hypertension, sex, self-identified race, and mtDNA haplogroup ancestry. Participants were normotensive (n = 107) and hypertensive (n = 108) African American and White adults from the Healthy Aging in Neighborhoods of Diversity across the Life Span study. ccf-mtDNA levels were higher in African American participants compared with White participants in both plasma and EVs, but ccf-mtDNA levels were not related to hypertension. EV mtDNA levels were highest in African American participants with African mtDNA haplogroup. Circulating inflammatory protein levels were altered with mtDNA haplogroup, race, and EV mtDNA. Our findings highlight that race is a social construct and that ancestry is crucial when examining health and biomarker differences between groups.http://www.sciencedirect.com/science/article/pii/S2589004223028018Biological sciencesBiochemistryMolecular biologyImmunologyCell biology |
| spellingShingle | Anjali M. Byappanahalli Victor Omoniyi Nicole Noren Hooten Jessica T. Smith Nicolle A. Mode Ngozi Ezike Alan B. Zonderman Michele K. Evans Extracellular vesicle mitochondrial DNA levels are associated with race and mitochondrial DNA haplogroup iScience Biological sciences Biochemistry Molecular biology Immunology Cell biology |
| title | Extracellular vesicle mitochondrial DNA levels are associated with race and mitochondrial DNA haplogroup |
| title_full | Extracellular vesicle mitochondrial DNA levels are associated with race and mitochondrial DNA haplogroup |
| title_fullStr | Extracellular vesicle mitochondrial DNA levels are associated with race and mitochondrial DNA haplogroup |
| title_full_unstemmed | Extracellular vesicle mitochondrial DNA levels are associated with race and mitochondrial DNA haplogroup |
| title_short | Extracellular vesicle mitochondrial DNA levels are associated with race and mitochondrial DNA haplogroup |
| title_sort | extracellular vesicle mitochondrial dna levels are associated with race and mitochondrial dna haplogroup |
| topic | Biological sciences Biochemistry Molecular biology Immunology Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223028018 |
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