Different mutational characteristics of the subsets of EGFR-tyrosine kinase inhibitor sensitizing mutation-positive lung adenocarcinoma

Different mutational characteristics of the subsets of EGFR-tyrosine kinase inhibitor sensitizing mutation-positive lung adenocarcinoma

Abstract Background A subset of lung adenocarcinoma with EGFR-tyrosine kinase inhibitor sensitizing mutations (mEGFR) is common in non-smokers and women, suggesting that mutational stressors other than smoking are involved. Methods Targeted sequencing using a custom panel containing 70 cancer-relate...

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Bibliographic Details
Main Authors: Eun Young Kim, Arum Kim, Gaeun Lee, Hangsuck Lee, Yoon Soo Chang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Cancer
Subjects:
EGFR
Lung adenocarcinoma
Mutational signatures
Next-generation sequencing
Sensitizing mutation
Tyrosine kinase inhibitor
Online Access:http://link.springer.com/article/10.1186/s12885-018-5116-9

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http://link.springer.com/article/10.1186/s12885-018-5116-9

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