Concentration and Duration of Indoxyl Sulfate Exposure Affects Osteoclastogenesis by Regulating NFATc1 via Aryl Hydrocarbon Receptor

Concentration and Duration of Indoxyl Sulfate Exposure Affects Osteoclastogenesis by Regulating NFATc1 via Aryl Hydrocarbon Receptor

Indoxyl sulfate (IS) is a chronic kidney disease (CKD)-specific renal osteodystrophy metabolite that affects the nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), a transcription factor promoting osteoclastogenesis. However, the mechanisms underlying the regulation of NFATc1 by IS remain...

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Bibliographic Details
Main Authors: Wen-Chih Liu, Jia-Fwu Shyu, Paik Seong Lim, Te-Chao Fang, Chien-Lin Lu, Cai-Mei Zheng, Yi-Chou Hou, Chia-Chao Wu, Yuh-Feng Lin, Kuo-Cheng Lu
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
aryl hydrocarbon receptor
indoxyl sulfate
osteoclast
chronic kidney disease
NFATc1
Online Access:https://www.mdpi.com/1422-0067/21/10/3486

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https://www.mdpi.com/1422-0067/21/10/3486

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