α-Fetoprotein-Producing Endometrial Carcinoma Is Associated With Fetal Gut-Like and/or Hepatoid Morphology, Lymphovascular Infiltration, TP53 Abnormalities, and Poor Prognosis: Five Cases and Literature Review

α-Fetoprotein-Producing Endometrial Carcinoma Is Associated With Fetal Gut-Like and/or Hepatoid Morphology, Lymphovascular Infiltration, TP53 Abnormalities, and Poor Prognosis: Five Cases and Literature Review

The clinicopathological, immunohistochemical, and molecular characteristics of α-fetoprotein (AFP)-producing endometrial carcinoma (AFP+ EC) are poorly understood. From 284 cases of endometrial carcinoma in our pathology archive, we identified five cases (1.8%) of AFP+ EC with fetal gut–like (4/5) a...

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Bibliographic Details
Main Authors: Tomoyuki Otani, Kosuke Murakami, Naoki Shiraishi, Man Hagiyama, Takao Satou, Mitsuru Matsuki, Noriomi Matsumura, Akihiko Ito
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Medicine
Subjects:
endometrial cancer
uterine corpus
alpha-fetoprotein (AFP)
fetal gut-like
enteroblastic
hepatoid
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.799163/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.799163/full

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