Exploration of 2D and 3D-QSAR analysis and docking studies for novel dihydropteridone derivatives as promising therapeutic agents targeting glioblastoma

Exploration of 2D and 3D-QSAR analysis and docking studies for novel dihydropteridone derivatives as promising therapeutic agents targeting glioblastoma

Background: Dihydropteridone derivatives represent a novel class of PLK1 inhibitors, exhibiting promising anticancer activity and potential as chemotherapeutic drugs for glioblastoma.Objective: The aim of this study is to develop 2D and 3D-QSAR models to validate the anticancer activity of dihydropt...

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Bibliographic Details
Main Authors: Meichen Pan, Lingxue Cheng, Yiguo Wang, Chunyi Lyu, Chao Hou, Qiming Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
glioblastoma
drug design
dihydropteridone derivatives
QSAR
molecule docking
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1249041/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1249041/full

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