Gastrodin From Gastrodia elata Enhances Cognitive Function and Neuroprotection of AD Mice via the Regulation of Gut Microbiota Composition and Inhibition of Neuron Inflammation

Gastrodin From Gastrodia elata Enhances Cognitive Function and Neuroprotection of AD Mice via the Regulation of Gut Microbiota Composition and Inhibition of Neuron Inflammation

Gastrodin (Gas) is known to exhibit neuroprotective effects in Alzheimer’s disease (AD). However, the detailed mechanism of action is still unclear. In the present study, we focused on the microbiome–gut–brain axis to investigate the mechanism of action of Gas using a D-galactose (Dgal)–induced AD m...

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Bibliographic Details
Main Authors: Opeyemi B. Fasina, Jianyu Wang, Jianxia Mo, Hiroyuki Osada, Hiroshi Ohno, Wensheng Pan, Lan Xiang, Jianhua Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
AD mice
gut microbiota
memory
neuroinflammation
microglial cell
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.814271/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.814271/full

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