DMC-siERCC2 hybrid nanoparticle enhances TRAIL sensitivity by inducing cell cycle arrest for glioblastoma treatment

DMC-siERCC2 hybrid nanoparticle enhances TRAIL sensitivity by inducing cell cycle arrest for glioblastoma treatment

ERCC2 plays a pivotal role in DNA damage repair, however, its specific function in cancer remains elusive. In this study, we made a significant breakthrough by discovering a substantial upregulation of ERCC2 expression in glioblastoma (GBM) tumor tissue. Moreover, elevated levels of ERCC2 expression...

Full description

Bibliographic Details
Main Authors: Meihui Song, Tengfei Wang, Tao Liu, Ting Lei, Xu Teng, Qian Peng, Qihui Zhu, Feng Chen, Guifang Zhao, Kaishu Li, Ling Qi
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
GBM
ERCC2
Cell cycle
CDK4
TRAIL
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224003548

Internet

http://www.sciencedirect.com/science/article/pii/S0753332224003548

Similar Items