The molecular chaperone GRP78/BiP in the development of chemoresistance: mechanism and possible treatment

Treatment of several types of cancer such as lung, breast, prostate and pancreas has shown notable progresses in the past decades. However, after an initial response, tumors eventually became resistant to chemotherapy. This phenomenon, known as chemoresistance, accounts for the death of most cancer...

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Bibliographic Details
Main Authors: Corinna eRoller, Danilo eMaddalo
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00010/full