Attenuated Mycobacterium tuberculosis vaccine protection in a low-dose murine challenge model

Attenuated Mycobacterium tuberculosis vaccine protection in a low-dose murine challenge model

Summary: Bacillus Calmette–Guérin (BCG) remains the only approved tuberculosis (TB) vaccine despite limited efficacy. Preclinical studies of next-generation TB vaccines typically use a murine aerosol model with a supraphysiologic challenge dose. Here, we show that the protective efficacy of a live a...

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Bibliographic Details
Main Authors: Samuel J. Vidal, Daniel Sellers, Jingyou Yu, Shoko Wakabayashi, Jaimie Sixsmith, Malika Aid, Julia Barrett, Sage F. Stevens, Xiaowen Liu, Wenjun Li, Courtney R. Plumlee, Kevin B. Urdahl, Amanda J. Martinot, Dan H. Barouch
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Immunology
Medical microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223010404

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223010404

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