Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes

Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes

Summary: Ibrutinib (IB) is an oral Bruton's tyrosine kinase (BTK) inhibitor that has demonstrated benefit in B cell cancers, but is associated with a dramatic increase in atrial fibrillation (AF). We employed cell-specific differentiation protocols and optical mapping to investigate the effects...

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Detalles Bibliográficos
Main Authors: Sanam Shafaattalab, Eric Lin, Effimia Christidi, Haojun Huang, Yulia Nartiss, Analucia Garcia, Jeehon Lee, Stephanie Protze, Gordon Keller, Liam Brunham, Glen F. Tibbits, Zachary Laksman
Formato: Artigo
Idioma:English
Publicado: Elsevier 2019-05-01
Series:Stem Cell Reports
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2213671119300967

Internet

http://www.sciencedirect.com/science/article/pii/S2213671119300967

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