Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes

Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes

Summary: Ibrutinib (IB) is an oral Bruton's tyrosine kinase (BTK) inhibitor that has demonstrated benefit in B cell cancers, but is associated with a dramatic increase in atrial fibrillation (AF). We employed cell-specific differentiation protocols and optical mapping to investigate the effects...

Celý popis

Podrobná bibliografie
Hlavní autoři: Sanam Shafaattalab, Eric Lin, Effimia Christidi, Haojun Huang, Yulia Nartiss, Analucia Garcia, Jeehon Lee, Stephanie Protze, Gordon Keller, Liam Brunham, Glen F. Tibbits, Zachary Laksman
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2019-05-01
Edice:Stem Cell Reports
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2213671119300967

Internet

http://www.sciencedirect.com/science/article/pii/S2213671119300967

Podobné jednotky