Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes
Summary: Ibrutinib (IB) is an oral Bruton's tyrosine kinase (BTK) inhibitor that has demonstrated benefit in B cell cancers, but is associated with a dramatic increase in atrial fibrillation (AF). We employed cell-specific differentiation protocols and optical mapping to investigate the effects...
| Main Authors: | , , , , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
Elsevier
2019-05-01
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| 丛编: | Stem Cell Reports |
| 在线阅读: | http://www.sciencedirect.com/science/article/pii/S2213671119300967 |