Upregulating Noxa by ER stress, celastrol exerts synergistic anti-cancer activity in combination with ABT-737 in human hepatocellular carcinoma cells.

Upregulating Noxa by ER stress, celastrol exerts synergistic anti-cancer activity in combination with ABT-737 in human hepatocellular carcinoma cells.

The human hepatocellular carcinoma (HCC) represents biologically aggressive and chemo-resistant cancers. Owing to the low affinity with the apoptotic factor Mcl-1, the BH3 mimetic drug ABT-737 failed to exert potent cancer-killing activities in variety of cancer models including HCC. The current stu...

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Bibliographic Details
Main Authors: Hong Zhu, Wei Yang, Ling-juan He, Wan-jing Ding, Lin Zheng, Si-da Liao, Ping Huang, Wei Lu, Qiao-jun He, Bo Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3527540?pdf=render

Internet

http://europepmc.org/articles/PMC3527540?pdf=render

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