Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer

Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer

Abstract Background The four major RNA adenosine modifications, i.e., m6A, m1A, alternative polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” enzymes and constitute critical mechanisms of epigenetic regulation in immune response and tumorigenesis. However, th...

Full description

Bibliographic Details
Main Authors: Huifang Chen, Jiameng Yao, Rujuan Bao, Yu Dong, Ting Zhang, Yanhua Du, Gaoyang Wang, Duan Ni, Zhenzhen Xun, Xiaoyin Niu, Youqiong Ye, Hua-Bing Li
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Molecular Cancer
Subjects:
RNA modification “writer”
Colorectal cancer
Tumor microenvironment
WM_Score
Drug sensitivity
Immunotherapy
Online Access:https://doi.org/10.1186/s12943-021-01322-w

Internet

https://doi.org/10.1186/s12943-021-01322-w

Similar Items