White matter injury but not germinal matrix hemorrhage induces elevated osteopontin expression in human preterm brains

Abstract Osteopontin (OPN) is a matricellular protein that mediates various physiological functions and is implicated in neuroinflammation, myelination, and perinatal brain injury. However, its expression in association with brain injury in preterm infants is unexplored. Here we examined the express...

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Bibliographic Details
Main Authors: Gisela Nilsson, Ana A. Baburamani, Mary A. Rutherford, Changlian Zhu, Carina Mallard, Henrik Hagberg, Regina Vontell, Xiaoyang Wang
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Acta Neuropathologica Communications
Subjects:
Online Access:https://doi.org/10.1186/s40478-021-01267-7