Immunohistochemistry and oxygen saturation endoscopic imaging reveal hypoxia in submucosal invasive esophageal squamous cell carcinoma

Abstract Background Hypoxic microenvironment is prominent in advanced esophageal squamous cell carcinoma (ESCC). However, it is unclear whether ESCC becomes hypoxic when it remains in the mucosal layer or as it invades the submucosal layer. We aimed to investigate whether intramucosal (Tis‐T1a) or s...

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Bibliographic Details
Main Authors: Nobuhisa Minakata, Shingo Sakashita, Masashi Wakabayashi, Yuka Nakamura, Hironori Sunakawa, Yusuke Yoda, Genichiro Ishii, Tomonori Yano
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Cancer Medicine
Subjects:
Online Access:https://doi.org/10.1002/cam4.6217