The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection

The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection

Abstract Background The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the COVID-19 pandemic, an early substitution in the genome was the D614G change in the spike protein, associated with an increase in transmissibility....

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Bibliographic Details
Main Authors: Hannah Goldswain, Xiaofeng Dong, Rebekah Penrice-Randal, Muhannad Alruwaili, Ghada T. Shawli, Tessa Prince, Maia Kavanagh Williamson, Jayna Raghwani, Nadine Randle, Benjamin Jones, I’ah Donovan-Banfield, Francisco J. Salguero, Julia A. Tree, Yper Hall, Catherine Hartley, Maximilian Erdmann, James Bazire, Tuksin Jearanaiwitayakul, Malcolm G. Semple, Peter J. M. Openshaw, J. Kenneth Baillie, ISARIC4C Investigators, Stevan R. Emmett, Paul Digard, David A. Matthews, Lance Turtle, Alistair C. Darby, Andrew D. Davidson, Miles W. Carroll, Julian A. Hiscox
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Genome Biology
Subjects:
SARS-CoV-2
Evolution
Selection
Spike protein
Polymerase
NSP12
Online Access:https://doi.org/10.1186/s13059-023-02881-5

Internet

https://doi.org/10.1186/s13059-023-02881-5

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