A single aromatic residue in sgp130Fc/olamkicept allows the discrimination between interleukin-6 and interleukin-11 trans-signaling

A single aromatic residue in sgp130Fc/olamkicept allows the discrimination between interleukin-6 and interleukin-11 trans-signaling

Summary: Blocking the activity of cytokines is an efficient strategy to combat inflammatory diseases. Interleukin-6 (IL-6) fulfills its pro-inflammatory properties via its soluble receptor (IL-6 trans-signaling). The selective trans-signaling inhibitor olamkicept (sgp130Fc) is currently in clinical...

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Bibliografische gegevens
Hoofdauteurs: Juliane Lokau, Yvonne Garbers, Joachim Grötzinger, Christoph Garbers
Formaat: Artikel
Taal:English
Gepubliceerd in: Elsevier 2021-11-01
Reeks:iScience
Onderwerpen:
Biochemistry
Medical biochemistry
Immunology
Cell biology
Online toegang:http://www.sciencedirect.com/science/article/pii/S2589004221012785

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http://www.sciencedirect.com/science/article/pii/S2589004221012785

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