Melatonin protects human nucleus pulposus cells from pyroptosis by regulating Nrf2 via melatonin membrane receptors

Melatonin protects human nucleus pulposus cells from pyroptosis by regulating Nrf2 via melatonin membrane receptors

Aims: This study was performed to explore the effect of melatonin on pyroptosis in nucleus pulposus cells (NPCs) and the underlying mechanism of that effect. Methods: This experiment included three patients diagnosed with lumbar disc herniation who failed conservative treatment. Nucleus pulposus t...

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Bibliographic Details
Main Authors: Zhibiao Bai, Zeyu Shou, Kai Hu, Jiahuan Yu, Hongming Meng, Chun Chen
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2023-03-01
Series:Bone & Joint Research
Subjects:
melatonin
intervertebral disc degeneration
pyroptosis
transcription factor
nrf2
nucleus pulposus cells
western blot
hydrogen peroxide
staining
nucleus pulposus tissues
interleukin
aggrecan
collagen type ii
reactive oxygen species
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.123.BJR-2022-0199.R1

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.123.BJR-2022-0199.R1

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