Enhanced medullary and extramedullary granulopoiesis sustain the inflammatory response in lupus nephritis

Objectives In SLE, deregulation of haematopoiesis is characterised by inflammatory priming and myeloid skewing of haematopoietic stem and progenitor cells (HSPCs). We sought to investigate the role of extramedullary haematopoiesis (EMH) as a key player for tissue injury in systemic autoimmune disord...

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Main Authors: Dimitrios T Boumpas, Maria Grigoriou, Aggelos Banos, Anastasia Filia, Pavlos Pavlidis, Ioannis Mitroulis, Jörn Walter, Stavros A Doumas, Eleni Zervopoulou, Danae Yiannakou, Gilles Gasparoni, Harikleia Gakiopoulou
Format: Article
Language:English
Published: BMJ Publishing Group 2024-03-01
Series:Lupus Science and Medicine
Online Access:https://lupus.bmj.com/content/11/1/e001110.full