In Vivo Ca<sub>V</sub>3 Channel Inhibition Promotes Maturation of Glucose-Dependent Ca<sup>2+</sup> Signaling in Human iPSC-Islets

In Vivo Ca<sub>V</sub>3 Channel Inhibition Promotes Maturation of Glucose-Dependent Ca<sup>2+</sup> Signaling in Human iPSC-Islets

Ca<sub>V</sub>3 channels are ontogenetically downregulated with the maturation of certain electrically excitable cells, including pancreatic β cells. Abnormally exaggerated Ca<sub>V</sub>3 channels drive the dedifferentiation of mature β cells. This led us to question whether...

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Bibliographic Details
Main Authors: Kaixuan Zhao, Yue Shi, Jia Yu, Lina Yu, Martin Köhler, Amber Mael, Anthony Kolton, Thomas Joyce, Jon Odorico, Per-Olof Berggren, Shao-Nian Yang
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomedicines
Subjects:
anterior chamber of the eye (ACE)
calcium channel
cytoplasmic-free Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>)
stem cell
in vivo confocal microscopy
islet
Online Access:https://www.mdpi.com/2227-9059/11/3/807

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https://www.mdpi.com/2227-9059/11/3/807

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