CXCL8 Promotes Endothelial-to-Mesenchymal Transition of Endothelial Cells and Protects Cells from Erastin-Induced Ferroptosis via CXCR2-Mediated Activation of the NF-κB Signaling Pathway

CXCL8 Promotes Endothelial-to-Mesenchymal Transition of Endothelial Cells and Protects Cells from Erastin-Induced Ferroptosis via CXCR2-Mediated Activation of the NF-κB Signaling Pathway

CXCL8-CXCR1/CXCR2 signaling pathways might form complex crosstalk among different cell types within the ovarian tumor microenvironment, thereby modulating the behaviors of different cells. This study aimed to investigate the expression pattern of CXCL8 in the ovarian tumor microenvironment and its i...

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Bibliographic Details
Main Authors: Hai-zhou Ji, Li Chen, Mi Ren, Sang Li, Tong-yu Liu, Hong-ju Chen, Hui-hui Yu, Yang Sun
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceuticals
Subjects:
CXCL8
CXCR2
NF-κB
ferroptosis
endothelial cells
Online Access:https://www.mdpi.com/1424-8247/16/9/1210

Internet

https://www.mdpi.com/1424-8247/16/9/1210

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