The Flexible, Extended Coil of the PDZ-Binding Motif of the Three Deadly Human Coronavirus E Proteins Plays a Role in Pathogenicity

The Flexible, Extended Coil of the PDZ-Binding Motif of the Three Deadly Human Coronavirus E Proteins Plays a Role in Pathogenicity

The less virulent human (h) coronaviruses (CoVs) 229E, NL63, OC43, and HKU1 cause mild, self-limiting respiratory tract infections, while the more virulent SARS-CoV-1, MERS-CoV, and SARS-CoV-2 have caused severe outbreaks. The CoV envelope (E) protein, an important contributor to the pathogenesis of...

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Bibliographic Details
Main Authors: Dewald Schoeman, Ruben Cloete, Burtram C. Fielding
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Viruses
Subjects:
human coronaviruses
envelope protein
PDZ-binding motif (PBM)
homology-based modelling
docking
HADDOCK
Online Access:https://www.mdpi.com/1999-4915/14/8/1707

Internet

https://www.mdpi.com/1999-4915/14/8/1707

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