An antigen-specific immunotherapeutic, AKS-107, deletes insulin-specific B cells and prevents murine autoimmune diabetes

An antigen-specific immunotherapeutic, AKS-107, deletes insulin-specific B cells and prevents murine autoimmune diabetes

IntroductionThe antigen-presenting cell function of insulin-reactive B cells promotes type 1 diabetes (T1D) in non-obese diabetic (NOD) mice by stimulating pathogenic T cells leading to destruction of insulin-producing β-cells of pancreatic islets.Methods/ResultsTo target insulin-reactive B cells, A...

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Bibliographic Details
Main Authors: David G. Alleva, Andrea R. Delpero, Thillainaygam Sathiyaseelan, Sylaja Murikipudi, Thomas M. Lancaster, Mark A. Atkinson, Clive H. Wasserfall, Liping Yu, Ramya Ragupathy, Rachel H. Bonami, Todd C. Zion
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
autoreactive B cell
autoimmunity
type 1 diabetes
Fc-fusion protein
antigen specific immunotherapeutic
insulin autoantigen
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1367514/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1367514/full

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