Immuno-Contexture and Immune Checkpoint Molecule Expression in Mismatch Repair Proficient Colorectal Carcinoma

Immuno-Contexture and Immune Checkpoint Molecule Expression in Mismatch Repair Proficient Colorectal Carcinoma

Colorectal carcinoma (CRC) represents a lethal disease with heterogeneous outcomes. Only patients with mismatch repair (MMR) deficient CRC showing microsatellite instability and hyper-mutated tumors can obtain clinical benefits from current immune checkpoint blockades; on the other hand, immune- or...

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Bibliographic Details
Main Authors: Mauro Giacomelli, Matilde Monti, Diego Cesare Pezzola, Silvia Lonardi, Mattia Bugatti, Francesco Missale, Rossella Cioncada, Laura Melocchi, Viviana Giustini, Vincenzo Villanacci, Carla Baronchelli, Stefania Manenti, Luisa Imberti, Emanuele Giurisato, William Vermi
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cancers
Subjects:
colorectal cancer
mismatch repair
microsatellite instability
immune checkpoint
double negative T cells
tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/15/12/3097

Internet

https://www.mdpi.com/2072-6694/15/12/3097

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