Sensitization of Non-Small Cell Lung Cancer Cells to Gefitinib and Reversal of Epithelial–Mesenchymal Transition by Aloe-Emodin Via PI3K/Akt/TWIS1 Signal Blockage

Sensitization of Non-Small Cell Lung Cancer Cells to Gefitinib and Reversal of Epithelial–Mesenchymal Transition by Aloe-Emodin Via PI3K/Akt/TWIS1 Signal Blockage

ObjectiveTo explore the impacts of AE (aloe-emodin) in gefitinib-resistant NSCLC (non-small cell lung cancer) cells and the corresponding mechanism.MethodsPC9 and PC9-GR cells were cultured and treated by gefitinib, AE, or the combination of the two drugs. Then, viability, apoptosis, migration and i...

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Bibliographic Details
Main Authors: Minghui Peng, Zhuifeng Zheng, Shaoyang Chen, Le Fang, Rongxiu Feng, Lijun Zhang, Qingnan Tang, Xuewen Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
aloe-emodin
gefitinib
NSCLC
drug resistance
EMT
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.908031/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.908031/full

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